Qunyuan Xu, Ph.D.
Professor, Capital Medical University, Beijing, China                                           
Phone: 86-10-8391-1464    
Fax: 86-10-8391-1464
E-Mail: xuqy@ccum.edu.cn
Address: Capital Medical University, 10 Xitoutiao, You An Men, Beijing, 100069, PR.China

Summary:
Dr. Qunyuan Xu graduated from Peking University School of Medicine with a M.D. degree in 1963. He received his Ph.D. degree in neuroscience at Karolinska Institute (Stockholm, Sweden) in 1988. His research mainly focuses on neural restoration in the CNS by stem cells and tissue engineering, and neural restoration in brain tissue for animal model of Parkinson’s Diseases. He is the director of Beijing Center of Neural Regeneration & Repair. He was the president of Capital Medical University from 1988 to 2002. He has won numerous awards, including the title of Advanced Researcher (awarded by Chinese Ministry of Education) and the title of Specialist for Outstanding Contribution (awarded by Chinese Ministry of Personnel).

Research Interests:
1. Neural Restoration in The CNS by Stem Cells and Tissue Engineering
The research aim in this direction is development of a strategy of stem cells and tissue engineering, toward the prospect to restore, maintain, or improve neural tissue function in the CNS. It is to focus on creating a permissive environment for regeneration, which would make that the therapy incorporates multiple cues into unique devices that more closely mimic native brain and spinal cord, and hopefully would also be interactive and programmable, and thus capable of seamless communication with surrounding or grafted tissues. With regard to biodegradable tissue engineering scaffolds, a three dimensional hyaluronic acid (HA) based hydrogel and PLGA microspheres bringing various active molecules are of especial concern in our lab. The stem cells with different origins are explored to be grafted, together with the scaffolds, for improvement of neural regeneration in injured brain or spinal cord.

2. Neural Restoration in brain tissue for Animal Models of Parkinson’s Diseases
This direction is first to interpret the mechanism of progressive and selective injury in dopaminergic neurons in the brain of animal models of Parkinson’s disease (PD), by an intra-cerebral inflammation. The pathology and neural regeneration, especially of fiber circuits in the basal ganglia is then concerned. Different approaches including gene and cell therapies, are explored to rescue functional balance of the pathways in the basal ganglia of PD models.

Awards and Honors:
The Prizes for Progress of Science and Technology, awarded by Chinese Ministry of Public Health (1981, 1995, 1997, 2011)
The Prizes for Progress of Science and Technology, awarded by Beijing Municipal Government (1980, 1986, 1994, 1996, 1998, 2001, 2003, 2010)
The Prize for Outstanding Achievement of Teaching, awarded by Beijing Municipal Government (1993, 2000, 2002)
The Prize for Popular Science Books, awarded by General Office of News & Publication, P. R. China (2003)
The Title of Model Worker, awarded by Beijing Municipal Government (1984)
The Title of Advanced Researcher, awarded by Chinese Ministry of Education (1989)
The Title of Chinese Advanced Researcher, awarded by China Association for Science and Technology (2010)
The Title of Specialist for Outstanding Contribution, awarded by Chinese Ministry of Personnel (1994)   
Honorary Member of Board of Italian Association of Anatomists (1999)
Honorary Member of Board of Romanian Society of Anatomy (2000)
Honorary Doctor of University of Oradea, Romania (2001)
Honorary Professor of University of Arad, Romania (2002)

Recent publications (As corresponding author):

1.    L Ju, H Zeng, Y Chen, Y Wu, B Wang*, Q Xu*, Dual Polarization of Microglia Isolated from Mixed Glial Cell Cultures. J Neurosci Res, 2015,93:1345-1352.
2.    Y Wu, J Wu, R Ju, Z Chen, Q Xu*, Comparison of intracerebral transplantation effects of different stem cells on rodent stroke models. Cell Biochemistry and Function. Cell Biochem and Function, 2015,33:174-182.
3.    R Huang, J Zhao, L Ju, Y Wen, Q Xu∗, The influence of GAP-43 on orientation of cell division through G proteins. Inter J Develop Neurosci, 2015, 47:333-339.
4.    N Yao, Y Wu, Y Zhou, Li Ju, Y Liu, R Ju, D Duan, Q Xu∗, Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson's disease. Brain Res, 2015, 1625:255-274.
5.    Y Wen, S Yu, Y Wu, R Ju, H Wang, Y Liu, Y Wang, Q Xu*, Spinal cord injury repair by implantation of structured hyaluronic acid scaffold with PLGA microspheres in the rat. Cell Tissue Res, 2015, DOI 10.1007/s00441-015-2298-1.