Hongxing Lei, PhD, born in 1970, “100 talent” professor of Beijing Institute of Genomics, Chinese Academy of Science.
[Education & Research experience] B.E. from Huanzhong University of Science and Technology (biomedical engineering, 1991), PhD from Kansas State University (biochemistry, 2003). Research assistant of bioinformatics at AMMS, Beijing(1991-1998).Postdoctoral researcher of computational biology at University of Delaware and UC Davis(2003-2008). Principle investigator at Beijing Institute of Genomics(2008-present).

Editorial duties

Associate editor, Journal of Alzheimer’s Disease; Associate editor-in-chief, Genomics, Proteomics & Bioinformatics.

Research directions & achievements

Research has always been in bioinformatics and computational biology since 1991.Published over 50 SCI papers in reputable journals such as PNAS, JACS, JMB, BJ，and JAD. Main contribution includes：1） Achieved the first sub-angstrom folding of a native protein by computer simulation (PNAS 2007, etc)，Led the early investigation of amyloid aggregation by computer simulation（JACS 2005, etc）. 2）Proposed novel disease mechanism for AD based on comprehensive analysis of brain transcriptome data（JAD 2012, etc）.3）Proposed characteristic transformation of AD and VaD blood (JAD 2013 & MN 2016 online). 4）Proposed novel genetic risks for AD based on the analysis of GWAS and transcriptome data（JAD 2014, etc）.5）Constructed AlzBase website for the research community（MN 2016, etc）。

Representative publications
1.     H.-B. Luo, G.-C. Han, J.-J. Wang, F. Zeng, Y.-M. Li, S.-J. Saho, F.-H. Song, Z.-X. Bai, X. Peng, Y.-J. Wang, X.-Q. Shi and H.-X. Lei*. (2015) Common aging signature in the peripheral blood of vascular dementia and Alzheimer’s disease. Mol Neurobiol online.
2.     Z.-X. Bai, G.-C. Han, B. Xie, J.-J. Wang, F.-H. Song, X. Peng and H.-X. Lei*. (2016) AlzBase: an integrative database for gene dysregulation in Alzheimer’s disease. Mol Neurobiol 53(1), 310-319.
3.     J.-Y. Sun, F.-H. Song, J.-J. Wang, G.-C. Han, Z.-X. Bai, B. Xie, X.-M. Feng, J.-P. Jia, Y. Duan and H.-X. Lei*. (2014) Hidden risk genes with high order intragenic epistasis in Alzheimer’s disease. J Alzheimers Dis, 41:1039-1056.
4.     J.-Y. Sun, X.-M. Feng, D.-P. Liang, Y. Duan and H.-X. Lei*. (2012) Down-regulation of energy metabolism in Alzheimer’s disease is a protective response of neurons to the microenvironment. J Alzheimers Dis，28, 389-402
5.     H.-X. Lei, C. Wu, H.-G. Liu and Y. Duan. (2007) Folding free energy landscape of HP35 from molecular dynamics simulations. PNAS, 104(12): 4925-4930