Chao-Yu Miao, MD, PhD

Professor and Chair, Department of Pharmacology
Second Military Medical University, Shanghai, China

Summary

Dr. Chao-Yu Miao is the chair, professor and PhD student supervisor at the Department of Pharmacology, Second Military Medical University, Shanghai, China. She is the chief expert for the national platform of preclinical pharmacodynamics, the head for the national excellent course of pharmacology, and the leader for the national key subject of pharmacology. She received MD degree in 1986 and PhD degree in 2000 at the Second Military Medical University, and worked in France as a postdoctoral fellow at the Institut de Recherches Servier in 2002 and as a visiting scientist at the Universite Claude Bernard Lyon 1 in 2003. She serves as the chair of the Cardiovascular Pharmacology Division of the Chinese Pharmacological Society, the deputy secretary-general of the Chinese Pharmacological Society, and the councilor of the Asian Society for Vascular Biology. She is the member of the Editorial Board for CNS Neuroscience & Therapeutics, Acta Pharmacologica Sinica, and Clinical and Experimental Pharmacology and Physiology.
Dr. Miao’s research mainly focuses on cardio-cerebro-vascular pharmacology. Her previous study has demonstrated the significant contribution of blood pressure variability to organ damage in hypertension, and developed a new drug for treatment of hypertension and prevention of stroke. Her recent research is to explore the potential implication of adipokines in pharmacotherapy of cardio-cerebro-vascular and metabolic diseases. Her team has identified nicotinamide phosphoribosyltransferase (NAMPT, also an adipokine known as visfatin) as a therapeutic target against stroke, established a high-throughput screening system for discovery of NAMPT-active compounds, and verified a drug candidate that is under development for treatment of stroke. Most recently, her team has discovered a novel adipokine Metrnl and demonstrated its function as an insulin sensitizer.
As a principal investigator, Dr. Miao has been supported by more than 20 research grants such as the National Science and Technology Major Project, the National Basic Research Program of China (973), and the Major Projects of the National Natural Science Foundation of China. She is the editor-in-chief of 10 books. She has published more than 150 papers in peer-reviewed journals such as Trends in Pharmacological Sciences, Annals of Neurology, European Heart Journal, Autophagy, and Diabetes. Her papers have been commented or cited by the articles published in Nature Medicine, Lancet, Lancet Neurology and so on for more than 3200 times. She has got 10 patents and one new drug certificate. She has been awarded science and technology prizes including one Second Class Prize of the National Natural Science Award, one First Class Prize of the Shanghai Science and Technology Progress Award, two Second Class Prizes of the Shanghai Natural Science Award, etc. She has won honors like the National Natural Science Foundation for Distinguished Young Scholar, the National Excellent Doctoral Thesis Award, the National Excellent Scientific and Technological Worker Award, the National Woman Pacesetter, the Army High Level Talent, the Shanghai Leading Talent, etc. She has supervised 34 postgraduate students; one of her PhD students obtained the National Natural Science Foundation for Excellent Young Scholar in 2014.

Recent Representative Publications

1)    Wang P, Miao CY*. NAMPT as a therapeutic target against stroke. Trends Pharmacol Sci. 2015; 36(12): 891-905.
2)    Li ZY, Song J, Zheng SL, Fan MB, Guan YF, Qu Y, Xu J, Wang P, Miao CY*. Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling. Diabetes. 2015; 64(12): 4011-22.
3)    Zhao Y, Guan YF, Zhou XM, Li GQ, Li ZY, Zhou CC, Wang P, Miao CY*. Regenerative neurogenesis after ischemic stroke promoted by nicotinamide phosphoribosyltransferase-nicotinamide adenine dinucleotide cascade. Stroke. 2015; 46(7): 1966-74.
4)    Wang X, Xu TY, Liu XZ, Zhang SL, Wang P, Li ZY, Guan YF, Wang SN, Dong GQ, Zhuo S, Le YY, Sheng CQ, Miao CY*. Discovery of novel inhibitors and fluorescent probe targeting NAMPT. Sci Rep. 2015; 5: 12657(16 pages).
5)    Xu TY, Zhang SL, Dong GQ, Liu XZ, Wang X, Lv XQ, Qian QJ, Zhang RY, Sheng CQ, Miao CY*. Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase. Sci Rep. 2015; 5: 10043(14 pages).